This annotated inquiry focuses on physical geography in general and on the relationship between early (pre-1700) Native American nations and their environments in particular through the compelling question “Does where you live matter?” The compelling question highlights the idea that geography is not a neutral entity. Environments can exert an influence on human existence, but they are not immune from change—human activity can modify the physical landscape. The reciprocal relationship between humans and their surroundings lies at the heart of this inquiry.